• A dark glass jar labeled Ancient + Brave Noble Collagen features a maroon and gold geometric design, highlighting joint support and active lifestyle. Contains 90 Type I Collagen capsules for Active Day Wellbeing.
  • A woman in purple activewear does yoga indoors. Text highlights a trial for Ancient + Brave Noble Collagen, showing over 90% of active participants aged 40-60 reported joint support thanks to its Type II Collagen formula.
  • A glass of water, a jar labeled Ancient + Brave Noble Collagen, and three white capsules sit on a table. Type II Collagen supports joint health and mobility, helping promote an active lifestyle.
  • A jar of Ancient + Brave Noble Collagen sits open on a wooden surface with white capsules beside it. Text: Easy to use—take one capsule daily for optimal dosage and joint support. Complements Type 1 collagen.
  • A jar and box of Ancient + Brave Noble Collagen, with Type II Collagen for joint support, sit on a beige surface. Above, checkmarks highlight: Innovative formula, Capsule form, and Pair with Type I Collagen.
  • A woman with straight brown hair, in a black turtleneck and gold pendant, smiles at the camera. Text beside her highlights joint support and an active lifestyle with Noble Collagen by Ancient + Brave, signed by Dr Jenna Macciochi.
  • A sunrise over snow-capped peaks with four certification logos and text: Ancient + Brave Noble Collagen—responsibly made for a happy planet, perfect for joint support and active living.
  • Noble Collagen by Ancient + Brave features a Supplement Facts label with Vitamin C, Manganese, Boswellia Serrata extract, Chicken Cartilage, and Type II Collagen per serving for joint support—perfect for an active lifestyle.

Noble Collagen

Capsules
30 servings
148 Ratings
From: $49.60

+ Aids joint health and comfort⁺
+ Elevates and prolongs an active lifestyle⁺
+ Type II Collagen blend
+ Convenient, once-daily capsule format

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Benefits

  • Type II Collagen to support strong, mobile and healthy joints⁺
  • Aids joint health and comfort⁺
  • Supports active lifestyles by promoting joint mobility⁺
  • Effortless usage: one capsule for optimal delivery and dosage
  • Easily integrated into True or Wild Collagen rituals

Why Take It

  • Type II Collagen is a targeted nutrient found specifically in cartilage. As we age, our bodies’ natural collagen production declines, which can lead to joint discomfort and stiffness.
  • Noble Collagen harnesses the power of Type II Collagen, which is shown in research  to help protect cartilage and promote joint comfort - supporting an active lifestyle .**
  • Our expert blend includes key nutrients, Vitamin C and Manganese, to aid natural collagen production and support healthy connective tissues. 
  • Boswellia Serrata, an ancient plant now backed by science, delivers focused support for joints and mobility.**

Consumer Study

90% Felt a difference in whole body*
93% Felt a noticeable reduction in joint discomfort*
93% Felt more confident in their ability to stay active as they age*
96% Experienced less joint stiffness after sitting for an extended period*

*Results from an 8 week consumer study of 30 healthy UK volunteers aged 40 to 60 to evaluate the efficacy of Noble Collagen. Individuals results may vary.

How to Use

  • Jar: 30 Capsules 
  • Serving Size: 1 Capsule
  • Servings Per Container: 30
  • Directions: Take 1 capsule per day, preferably with a meal.
  • Optional: Commit to consistency and use the Ritual Case as your daily self-care reminder.
  • Noble Collagen (Type II) can be balanced with True or Wild Collagen (Type I), offering a more comprehensive approach to joint health.

Ingredients & Nutritionals

Supplement Facts

Per Capsule % Daily Value
Vitamin C (as magnesium ascorbate) 12 mg 13%
Manganese (as manganese gluconate) 0.4 mg 17%
Boswelia Serrata (Indian Frankincense) 6:1 extract (resin) (Extract from 400 mg dry herb) 67 mg *
Standardized Chicken Cartilage 40 mg *
Undenatured Type II collagen 10 mg

Other Ingredients

Brown rice flour, capsule shell (hydroxypropyl methylcellulose).

Advice: Do not exceed the recommended stated daily dose. Dietary supplements are not a substitute for a varied diet and a healthy lifestyle. Not suitable for children. Consult a physician before use if you are pregnant, breastfeeding, have a medical condition or are taking any medications. KEEP OUT OF REACH OF CHILDREN. Do not use if the safety seal is broken or missing.

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Ingredients explained

Vitamin C Vitamin C

Vitamin C is essential for collagen production, improving the strength and flexibility of bones and cartilage while protecting joints from oxidative stress.

The most common form of Vitamin C, ascorbic acid, has a low absorption rate and can cause digestive discomfort. Instead, we've used a gentler, buffered version; magnesium ascorbate, which is easier on the gut and offers significantly better absorption.

Boswellia Boswellia

For centuries, Boswellia serrata or Indian Frankincense, has been a popular natural aid in Ayurvedic, Traditional Chinese, and Middle Eastern medicine.

Extracted as aromatic resin from the Boswellia tree, native to India and Africa, it is rich in boswellic acids, plant compounds studied for their potential role in joint comfort and mobility. Boswellia has been traditionally used to manage and support conditions like arthritis and joint discomfort. Recent research highlights its broader benefits in supporting immune health, making it a key ingredient in Noble Collagen.

Type II Collagen Type II Collagen

Undenatured Type II collagen is a form of collagen extracted from chicken sternum cartilage. UC-II collagen has been clinically studied to specifically support cartilage and joint function.

Type II collagen's triple-helix structure has a different mechanism of action from type I collagen peptides. It interacts with gut-associated lymphoid tissue (GALT) to help regulate immune responses to worn-out collagen fragments in the cartilage of joints, supporting joint comfort and easing the physical stresses associated with ageing.

Manganese Manganese

Manganese is a vital trace mineral involved in many physiological processes. It acts as a cofactor for enzymes that support antioxidant defence and plays a key role in bone formation and connective tissue health. Manganese helps build and maintain strong connective tissue and bones, essential for lasting joint strength and mobility.

Works well taken alongside

A 200g brown glass jar of Ancient + Brave True Collagen features a gold geometric face on a black label and contains hydrolyzed bovine collagen supplement powder to support joint health and skin elasticity.

True Collagen

4604 Ratings

100% Hydrolyzed Bovine Collagen Peptides
From: $46.40
View product
True Hydrate - 15 Packets

True Hydrate - 15 Packets

444 Ratings

Inspired by the natural electrolytes found in coconut water
From: $28.80
View product
  • A 200g brown glass jar of Ancient + Brave True Collagen features a gold geometric face on a black label and contains hydrolyzed bovine collagen supplement powder to support joint health and skin elasticity.
  • A woman with clear, glowing skin looks upward in a forest. Text highlights clinically proven benefits—100% hydration, improved elasticity, and brighter skin—after using Ancient + Brave True Collagen for whole body health.
  • A comparison chart of Ancient + Brave True Collagen (EU-sourced) vs. typical US collagen shows True Collagen meets five standards for joint support and skin elasticity. Above the chart, powder is poured into a mug.
  • A woman with closed eyes enjoys sunlight amid leaves. Ancient + Brave True Collagen users: 80% felt more energized, 77% noticed less hair breakage, and 70% saw improved sleep quality with joint support.
  • A vertical timeline highlights key wellness milestones with Ancient + Brave Wild Collagen: 6 weeks—gut, 8-12 weeks—skin, 3-6 months—joints, and 12+ months—bones; each phase marked by a simple line icon.
  • A hand pours Ancient + Brave True Collagen powder from a brown jar into a mug with a gold spoon. Add 6g to drinks as part of your morning ritual—its neutral taste and easy dissolving support whole body health.
  • A woman with straight brown hair, in a black top and gold necklace, smiles before a gray backdrop. Beside her is Dr Jenna Macciochi’s quote on how Ancient + Brave True Collagen supports skin elasticity with hydrolyzed bovine collagen.
  • A woman with blonde hair in a blue sweater enjoys the sun outside, holding a mug by a wooden railing. Text reads: Ancient + Brave True Collagen—wellness benefits for joint support, skin elasticity, and whole body health.
  • Ancient + Brave True Collagen bottle and box with gold spoon on beige surface. Features hydrolyzed bovine collagen for whole-body health, EU sourced, hormone/antibiotic free, non-GMO, 0g sugar, and third-party tested.
  • Sunlight streams through tall trees in a lush forest. Text reads: Ancient + Brave True Collagen—responsibly made for a happy planet, with four sustainability and ethical certifications, supporting whole body health with hydrolyzed bovine collagen.
  • Supplement Facts for Ancient + Brave True Collagen: Each 2 tsp (6g) serving delivers 20 calories, 30mg sodium, 5g protein, and 6g Hydrolyzed Bovine Collagen (Type I) to support whole body health. Contains about 33 servings per container.
  • A brown glass bottle of Ancient + Brave True Collagen features a black label with supplement facts—calories, sodium, protein, hydrolyzed bovine collagen for joint support—plus serving size, distributor details, and storage instructions.
  • Ancient + Brave True Collagen comes in an amber glass bottle with a black lid. The black label shows supplement facts, Hydrolyzed Bovine Collagen for whole body health, product info in white text, plus recycling and certification symbols.
  • A black label displays supplement facts for True Collagen by Ancient + Brave, listing serving size, calories, sodium, dosage instructions, and manufacturer/distributor info—formulated with hydrolyzed bovine collagen to support whole body health.
  • Back of an Ancient + Brave True Collagen box displaying product info, usage instructions, Hydrolyzed Bovine Collagen (Type I), ingredient and nutrition details, certifications, and barcode—all for whole body health on a dark background.
  • A black product box from Ancient + Brave displays True Collagen in white text, highlighting EU bovine Type I collagen, enzymatic hydrolysis for easy digestion, high bioavailability, no fillers, neutral flavor, and whole body health benefits.
  • A black and gold box of Ancient + Brave True Collagen showcases geometric design and highlights Hydrolyzed Bovine Collagen (Type I) sourced from EU cattle to support whole body health, with supplement facts displayed on the label.
True Collagen

+ Supports skin elasticity, energy, joints and hair⁺
+ Type I Hydrolyzed Bovine Collagen
+ EU sourced, free from growth hormones + antibiotics⁺
+ Neutral taste and odor, dissolves easily

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  • True Hydrate - 15 Packets
  • True Hydrate - 15 Packets
  • A woman holds a water bottle and Ancient + Brave True Hydrate Sachet against green plants, promoting a mineral blend with electrolytes for active lifestyles. Text highlights clinically proven hydration, less fatigue, and reduced inflammation.
  • A graphic titled Traceable Sourcing with three checkmarks: Intelligent mineral formula, Maximum absorption*, No artificial sweeteners. Below is Ancient + Brave True Hydrate Sachets—an electrolyte-rich blend for active lifestyles.
  • A brown promotional graphic for a electrolytes supplement powder. Text reads 'INTELLIGENT FORMULA' and lists ingredients: Coconut Water Powder, Chicory Root Inulin, Marine Magnesium, and Pink Himalayan Salt.
  • A woman with dark curly hair enjoys the outdoors, sipping from a clear bottle. Text: Start your day with Ancient + Brave True Hydrate Sachets—just add 6g to water for a refreshing mineral blend and natural coconut water flavor.
  • A hand holds an Ancient + Brave True Hydrate Sachet on a blue patterned cloth next to a glass of water. Text highlights its electrolyte-rich mineral blend for morning hydration, travel convenience, and support for active lifestyles.
  • A woman with straight brown hair in a black turtleneck and gold necklace smiles at the camera. To her left, a quote by Dr. Jenna Macciochi about electrolytes for active lifestyles promotes Ancient + Brave True Hydrate Sachets. The background is gray.
  • A close-up of ocean waves with text: Ancient + Brave True Hydrate Sachets—responsibly made for a happy planet and active lifestyles, with a hydrating mineral blend. Eco-certification logos: 1% for the Planet, B Corp, Climate Neutral, Buy Women Built.
  • The Ancient + Brave True Hydrate Sachets supplement facts label features a black and cream design, shows one sachet per serving (12 calories), highlights key electrolytes for active lifestyles, ingredient list, and provides a 15-day supply.
  • Back of an Ancient + Brave True Hydrate Sachets box, detailing its mineral electrolyte blend for active lifestyles, usage directions, Vegan and B Corp certifications, and disclaimers—all in white text on a dark background.
  • A tall, dark box for Ancient + Brave True Hydrate Sachets features white text on its mineral blend electrolyte formula and hydration benefits. At the bottom are a small mountain logo and the words “RISE RITUAL.”.
  • The Ancient + Brave True Hydrate Sachets box features a Supplement Facts label with nutritional info, electrolytes, a mineral blend for active lifestyles, as well as directions and warnings.
True Hydrate - 15 Packets

+ Utilizes natural electrolytes within coconut water
+ Hydrates and revitalizes body and mind⁺
+ Added minerals for daily energy⁺
+ No artificial flavors or sweeteners

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Trusted by experts

  • “I take Noble Collagen to support my joints and help me feel like me again.”

    Dame Kelly Holmes
    Double Olympic Champion

  • Most supplement companies rely on generic research, claiming their formulas will yield the same results. Ancient + Brave is an exception; they back their products with clinical trials, a level of integrity that is incredibly hard to find in the supplement industry.

    Dana James
    MS, CDN, CNS

  • “I’m so impressed by the integrity of Ancient + Brave, their formulations are pure, science-backed, and rooted in ancient wisdom. They truly embody what it means to nourish both body and soul.”

    Mona Sharma
    Nutritionist

  • "I love that Ancient + Brave pairs integrity with efficacy. Products that work and taste neutral that I can trust for myself and my clients."

    Shauna Falisa
    Celebrity Chef & Nutritionist

  • “Transparency, emphasis on quality and commitment to research sets Ancient and Brave apart as a wellness company consumers can trust to provide quality products that support the body throughout all seasons of life.”

    Erin Ogden MDA, RDN, LDN
    Dietitian Nutritionist, Ancient + Brave US

  • “When you honor and restore your internal ecosystem, you naturally begin to care for the world around you with greater awareness and compassion.”

    Madison Miller, M.S.
    Holistic Nutritionist, Ancient + Brave US

  • "As a dentist, I value products that are both science-backed and sustainably sourced. What sets them apart is their commitment to clean, high quality sourcing and thoughtful formulation. These aren’t just supplements, they’ve become simple daily rituals I look forward to."

    Dr. Tara Poostchi
    DDS, MS

  • "What I appreciate about Ancient + Brave is their focus on evidence - not just marketing. The clinical research is solid, the formulations are well thought out, and it’s a standard I feel good standing behind."

    Dr. Ariana Medizade
    PharmD, RPh, FNC

  • “With over 20 years' experience as a specialist in health, myself and the team have the powerful opportunity to create products that support both people and our planet.”

    Dr Jenna Macciochi
    VP of Science & Innovation, Ancient + Brave

  • “We are constantly expanding our research in nutrition and ingredients to ensure we are delivering the highest quality products that are pure, potent, and efficacious.”

    Jo Woodhurst
    VP of Nutrition & Education, Ancient + Brave

I take Noble Collagen to support my joints and help me feel like me again.

Dame Kelly Holmes
British Olympic Athlete

A closer look

  • A woman wearing a matching pink sports bra and leggings is practicing yoga indoors, holding one knee to her chest while standing. She appears focused and calm, with reflections visible on the window beside her.

    FULL-SPECTRUM SUPPORT

    Optimal joint health requires a full-spectrum approach. Our formula combines Type II Collagen for cartilage renewal, Boswellia for its active plant compounds, Manganese to support connective tissue, and Vitamin C for antioxidant protection – targeting all aspects of joint function.

  • A hand holds a white capsule near a blurred bottle in the background, with text overlay reading Clinically proven Type II Collagen.

    UC-II RESEARCH

    UC-II® collagen is backed by over 20 studies, including eight human clinical trials over two decades. Research highlights its benefits for animals, healthy individuals, and those with osteoarthritis. Studies have demonstrated that UC-II® improved joint flexion, range of motion, joint comfort and mobility.**

  • A person holds a jar labeled Noble Collagen in one hand and two capsules in the other, sitting at a wooden table in bright natural light.

    THE IMPORTANCE OF JOINT HEALTH

    Joints are pivotal junctions in our body that do more than just connect bone to bone; they enable the fluidity of motion that carry us through our days. From the simple act of walking to lifting a child, joint health is the silent foundation upon which our daily lives are built.

  • A woman with curly hair, wearing an off-the-shoulder black top and an olive green strap, smiles softly while sitting against a worn brick wall with a gray, weathered texture.

    STAYING ACTIVE AS WE AGE

    Staying active as we age is essential for a joyful, fulfilling life. Movement and mobility lay the foundation for independence, whether it’s the freedom of a morning run or the calm of a yoga flow. Embracing all forms of movement celebrates life’s potential, supporting both physical health and mental well-being.

  • A person holding a glass of water sits by a gold tray with a jar labeled Marine Collagen and several collagen capsules near a blue pool.

    THE HISTORY OF BOSWELLIA

    Boswellia, or Indian frankincense, has been valued for centuries in Ayurvedic and Middle Eastern medicine. It has long been used in sacred ceremonies and praised as 'Guggul' – a dried gum resin – in Sanskrit texts as early as 1700 BC, and is highly regarded for its plant properties.

Focus & Cognition | Clinical Trials

Everything you need to know about Type 1 + Type 2 collagen (and how they live in harmony)

Dip your toe in the world of collagen and you soon start to see that, beyond the well documented skin, joint and whole-body benefits, it’s more complex than expected. By our VP of Nutrition & Education, Jo Woodhurst. 
Read more
Everything you need to know about Type 1 + Type 2 collagen (and how they live in harmony)
5 Min read

FAQs

WHY IS NOBLE COLLAGEN IN A CAPSULE RATHER THAN IN POWDER FORM?

The reason our Noble Collagen is in a capsule is because it utilizes Type II collagen. This type does not need to be hydrolyzed to exert its action in the body. Its preserved structure in a capsule enables it to reach the gut intact**. Additionally, the recommended dose for Type II collagen is 40mg, and therefore is most suitable in capsule form.

WHAT IS (UC-II) TYPE II COLLAGEN, AND HOW LONG DOES IT TAKE TO WORK?

UC-II is a type of undenatured Type II Collagen commonly used  to support the integrity and flexibility of joint cartilage. Research has shown  improvements in joint comfort, mobility and flexibility  from only 3 weeks to 42 days** . The most significant, noticeable and sustained benefits may be gained after 3 months of long-term, consistent daily use**.  

IF I TAKE NOBLE COLLAGEN SHOULD I STILL TAKE TRUE COLLAGEN OR WILD COLLAGEN?

Yes, True and Wild contain Type I 'hydrolyzed' collagen peptides. Type II Collagen is described as 'undenatured' collagen. These serve different purposes in the body. While Type II is focused on targeted joint health, Type I provides general support to whole body health and generalized support for joints*. Those with specific health goals around joints and mobility would benefit from the additional, targeted benefits from Noble Collagen, alongside their True or Wild Collagen ritual.

WHERE DOES TYPE II COLLAGEN COME FROM?

Our Type II Collagen is sustainably sourced from chicken sternum cartilage. This source is specifically chosen because it naturally contains a high concentration of Type II Collagen, which is beneficial for joint health**.

IS NOBLE COLLAGEN SAFE TO TAKE DURING PREGNANCY OR BREASTFEEDING?

You should always speak to your health care provider before introducing any new supplements or dietary changes during pregnancy or breastfeeding. Due to ethical constraints, studies in pregnant and breastfeeding individuals are limited, so we are unable to make specific recommendations. If in doubt, please consult your healthcare provider.

ARE THERE ANY SIDE EFFECTS ASSOCIATED WITH THESE INGREDIENTS?

UC-II® and Boswellia are generally well tolerated when taken as directed. We always advise consulting your healthcare provider before starting any new supplement, especially for those with pre-existing medical conditions or whilst taking other medications.

IS THIS SUPPLEMENT VEGETARIAN/VEGAN-FRIENDLY?

This supplement contains collagen derived from chicken, so it is not vegetarian/vegan friendly.

WHAT IS THE DIFFERENCE BETWEEN TRUE/WILD AND NOBLE COLLAGEN?

Collagen is categorized into different 'types', with each grouping having its own unique characteristics. So far, at least 28 different types of collagen have been identified.  Type I Collagen is  the most abundant in skin, bone, teeth, ligaments, organs, and tendons**.  Type II Collagen is the primary type  found  in cartilage, and commonly used to support joint health and mobility**. Type I collagen is hydrolyzed (broken into smaller peptides for absorption), while Type II in Noble is undenatured and works through a different mechanism.**

Overall rating: 4.5 / 5 from 148 reviews.

AI Generated Review Summary

Noble Collagen provides significant relief for joint and knee pain, enhancing overall joint strength and comfort. Customers report notable improvements in joint mobility and a reduction in discomfort.

Summary topics

  • Joint and Knee Comfort (9%): Customers expressed appreciation for how the product made their knees and joints feel so much better and stronger.
  • Joint and Hip Pain Relief (22%): Based on a significant number of customers, the product has significantly reduced pain in joint and hip pain.
  • Collagen Effectiveness (22%): A significant number of customers stated that the collagen is great and helps with pain and joint discomfort.

Review topics: ["taste","feel","quality","issues","box","delivery","packaging","collagen","improvement","results","benefits","difference","skin","system","pain","joints","knees","capsules","effects","nails","supplement","powder","hips","hair","tablets","noticed","formula","use","discount","hrt"].

Review highlights

  • "Those annoying aches and pains I have felt since the menopause have now gone since taking the noble collagen." — FM
  • "Great formula and joint pain is much better x" — Fiona M.
  • "Knee joints feeling better when running and improvement in nails is fab." — Jill M.

Reviews

Great results

"Been troubled with OA for 30 years my hips particularly bad, standing up, getting in and out of cars had pain which stopped me dead. Other major joints, hands wrist,knees. My daughter recommended Collagen and sent me the link for this site. So I signed up for 3 months, worth a try I thought. Relieved capsules pretty quick and started taking them. After 12 days I realised that I had no pain in my hips, I was amazed at the speed they worked on me. Two weeks on and still no pain. What a difference for me. Still can't believe the relief I get from being pain free. Thanks. Jim"

— JAMES H. (5/5)

Fabulous product

"I have been struggling with aching knees for years, NHS not much help (usual comments!) 2 months after starting taking Noble Collagen the results are amazing! I won't say it's cured it, but the pain and range of motion have improved dramatically. I would highly recommend this product for joint issues."

— Jenni R. (5/5)

Noble collagen

"Fantastic product waited 3 months before giving a review. Skin glowing hair feeling thicker nails stronger and a little bit less stiffness in my knees!"

— Claudine M. (5/5)

Noble collagen results

"Just coming to the end of my first month of taking my Noble collagen and I have to say I have already noticed an improvement in my hip pain. I'm getting up after sitting or laying in bed with more ease than before. So I can't wait to see what the results will be after the full 90 days. I'm very happy 😁👍"

— TONI F. (5/5)

It makes a difference

"It’s proving a good decision to start on this regime . I use it alongside wild collagen"

— Mrs S. (5/5)

To early to see the

"To early to see the results. Easy to take capsules. The product itself is packaged lovely and has the appearance of a quality brand. ,"

— Clair G. (3/5)

Good quality product

"Been taking noble collegan for 3 weeks now, feeling as though I’ve a little more energy and less body aches. Good quality product and reasonable price and quick delivery"

— Jacqueline S. (5/5)

Really happy

"I’m really happy with this product. A bit early yet to see if it’s doing me any good but I love the ease of taking a tablet. I wanted collagen specifically for joints and this is perfect for me. Very happy"

— Lesley H. (5/5)

Not pleased

"I noticed my hair was not as thick and skin not as when I used another brand. In the meantime another batch was delivered. How do I send them back to you for a refund and cancel any further orrders?"

— Jennie S. (1/5)

Quality product and presentation

"Too early to rate benefits but very happy with other products from here"

— Michelle D. (5/5)

Q&A

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Noble Collagen

Type II Collagen

Lugo, J.P., Saiyed, Z.M., Lau, F.C. et al. (2013). Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr 10, 48. https://doi.org/10.1186/1550-2783-10-48

Schön, C., Knaub, K., Alt, W., Durkee, S., Saiyed, Z., & Juturu, V. (2022). UC-II undenatured type II collagen for knee joint flexibility: A multicenter, randomized, double-blind, placebo-controlled clinical study. Journal of Integrative and Complementary Medicine, 00(00), 1–9. https://doi.org/10.1089/jicm.2021.0365

Schön, C., Knaub, K., Alt, W., Durkee, S., Saiyed, Z., & Juturu, V. (2022). UC-II Undenatured Type II Collagen for Knee Joint Flexibility: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study. Journal of integrative and complementary medicine, 28(6), 540–548. https://doi.org/10.1089/jicm.2021.0365

Sadigursky, D., Magnavita, V. F. S., Sá, C. K. C., Monteiro, H. S., Braghiroli, O. F. M., & Matos, M. A. A. (2022). UNDENATURED COLLAGEN TYPE II FOR THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE. Acta ortopedica brasileira, 30(2), e240572. https://doi.org/10.1590/1413-785220223002240572

Martínez-Puig, D., Costa-Larrión, E., Rubio-Rodríguez, N., & Gálvez-Martín, P. (2023). Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge. Nutrients, 15(6), 1332. https://doi.org/10.3390/nu15061332

Pan, P., Wang, Y., Nyirenda, M. H., Saiyed, Z., Karimian Azari, E., Sunderman, A., Milling, S., Harnett, M. M., & Pineda, M. (2024). Undenatured type II collagen protects against collagen-induced arthritis by restoring gut-joint homeostasis and immunity. Communications biology, 7(1), 804. https://doi.org/10.1038/s42003-024-06476-z

Vitamin C NIH references:

Li, Y., & Schellhorn, H. E. (2007). New developments and novel therapeutic perspectives for vitamin C. The Journal of nutrition, 137(10), 2171–2184. https://doi.org/10.1093/jn/137.10.2171

Carr, A. C., & Frei, B. (1999). Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. The American journal of clinical nutrition, 69(6), 1086–1107. 

https://doi.org/10.1093/ajcn/69.6.1086

DePhillipo, N. N., Aman, Z. S., Kennedy, M. I., Begley, J. P., Moatshe, G., & LaPrade, R. F. (2018). Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthopaedic journal of sports medicine, 6(10), 2325967118804544. 

https://doi.org/10.1177/2325967118804544

Manganese EFSA/NIH references:

Buchman AL, (2006). Manganese. In: Modern nutrition in health and disease, tenth edition. Eds Shils ME, Shike M, Ross AC, Caballero B and Cousins RJ. Lippincott Williams and Wilkins,

Philadelphia, 326-331.

Combs GF, Norris LC and Heuser GF, (1942). The interrelationship of manganese, phosphatase and vitamin D in bone development. Journal of Nutrition, 23, 131-140.

Li, L., & Yang, X. (2018). The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions. Oxidative medicine and cellular longevity, 2018, 7580707. 

https://doi.org/10.1155/2018/7580707

Bae, Y. J., & Kim, M. H. (2008). Manganese supplementation improves mineral density of the spine and femur and serum osteocalcin in rats. Biological trace element research, 124(1), 28–34. 

https://doi.org/10.1007/s12011-008-8119-6

Boswellia Serrata

Siddiqui M. Z. (2011). Boswellia serrata, a potential antiinflammatory agent: an overview. Indian journal of pharmaceutical sciences, 73(3), 255–261.

https://doi.org/10.4103/0250-474X.93507

Kimmatkar, N., Thawani, V., Hingorani, L., & Khiyani, R. (2003). Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee: A randomized double-blind placebo-controlled trial. Phytomedicine, 10(1), 3–7. https://doi.org/10.1078/094471103321648593

Pérez-Piñero, S., Muñoz-Carrillo, J. C., Victoria-Montesinos, D., García-Muñoz, A. M., Andreu-Caravaca, L., Gómez, M., Schölzel, M., García-Guillén, A. I., & López-Román, F. J. (2023). Efficacy of Boswellia serrata Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial. Nutrients, 15(17), 3848. https://doi.org/10.3390/nu15173848

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